DNA replication stress restricts ribosomal DNA copy number
نویسندگان
چکیده
منابع مشابه
DNA replication stress restricts ribosomal DNA copy number
Ribosomal RNAs (rRNAs) in budding yeast are encoded by ~100-200 repeats of a 9.1kb sequence arranged in tandem on chromosome XII, the ribosomal DNA (rDNA) locus. Copy number of rDNA repeat units in eukaryotic cells is maintained far in excess of the requirement for ribosome biogenesis. Despite the importance of the repeats for both ribosomal and non-ribosomal functions, it is currently not know...
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Ecologists recognize the balance of nature as a complex system that arises from interacting and connected parts; disturbing the balance can affect other species in nonlinear and dynamic ways. Like ecosystems, the cell and genome are extensively connected by an abundance of molecular interactions. Upsetting the molecular balance, through changes in gene regulation, abnormal copy number variants,...
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Ribosomal DNA is one of the most variable regions in the human genome with respect to copy number. Despite the importance of rDNA for cellular function, we know virtually nothing about what governs its copy number, stability, and sequence in the mammalian genome due to challenges associated with mapping and analysis. We applied computational and droplet digital PCR approaches to measure rDNA co...
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Background: Based on the studies, variation in the mitochondrial DNA (mtDNA) copy number in peripheral blood leukocytes is associated with increased susceptibility to diseases including cancer. Opiate abusers are at high risk for diseases. In this study, we measured the mtDNA copy number in peripheral blood leukocytes in a group of opiate abusers compared with those in healthy individuals. Met...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2017
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1007006